Generalization of the Event-Based Carnevale-Hines Integration Scheme for Integrate-and-Fire Models

DOI10.1162/NECO.2009.07-08-815MaRDI QIDQ3497608zbMATH OpenOpenAlexDBLPWikidataFDO

Authors R. A. J. van Elburg, Arjen van Ooyen

Publication date 27 July 2009

Published in Neural Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0805.1561

Mathematics Subject Classification ID

Dynamical systems in biology (37N25) Neural biology (92C20)

Abstract: An event-based integration scheme for an integrate-and-fire neuron model with exponentially decaying excitatory synaptic currents and double exponential inhibitory synaptic currents has recently been introduced by Carnevale and Hines. This integration scheme imposes non-physiological constraints on the time constants of the synaptic currents it attempts to model which hamper the general applicability. This paper addresses this problem in two ways. First, we provide physical arguments to show why these constraints on the time constants can be relaxed. Second, we give a formal proof showing which constraints can be abolished. This proof rests on a generalization of the Carnevale-Hines lemma, which is a new tool for comparing double exponentials as they naturally occur in many cascaded decay systems including receptor-neurotransmitter dissociation followed by channel closing. We show that this lemma can be generalized and subsequently used for lifting most of the original constraints on the time constants. Thus we show that the Carnevale-Hines integration scheme for the integrate-and-fire model can be employed for simulating a much wider range of neuron and synapse type combinations than is apparent from the original treatment.

Recommendations

• Fast and exact simulation methods applied on a broad range of neuron models
• Event-Driven Simulations of Nonlinear Integrate-and-Fire Neurons
• Exact Simulation of Integrate-and-Fire Models with Exponential Currents
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• Exact Simulation of Integrate-and-Fire Models with Synaptic Conductances

Cites work

• Analytical Integrate-and-Fire Neuron Models with Conductance-Based Dynamics for Event-Driven Simulation Strategies
• Exact Simulation of Integrate-and-Fire Models with Synaptic Conductances
• Exact Subthreshold Integration with Continuous Spike Times in Discrete-Time Neural Network Simulations

Cited in

(2)

• Fast and exact simulation methods applied on a broad range of neuron models
• Toward unified hybrid simulation techniques for spiking neural networks

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