Group-sequential designs with an externally-driven change of primary endpoint

DOI10.1002/SIM.70337MaRDI QIDQ6856656zbMATH OpenFDO

Authors Amin Yarahmadi, Lori E. Dodd, Peter Horby, Thomas Jaki, Nigel Stallard

Publication date 18 February 2026

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

zbMATH Keywords

group-sequential stopping boundaryemerging disease clinical trialprimary endpoint changetype I error rate spending function

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

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