Group-sequential designs with an externally-driven change of primary endpoint

DOI10.1002/SIM.70337MaRDI QIDQ6856656zbMATH OpenFDO

Authors Amin Yarahmadi, Lori E. Dodd, Peter Horby, Thomas Jaki, Nigel Stallard

Publication date 18 February 2026

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.70337

zbMATH Keywords

emerging disease clinical trialgroup-sequential stopping boundaryprimary endpoint changetype I error rate spending function

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Design and analysis of group sequential tests based on the type I error spending rate function
• Discrete Sequential Boundaries for Clinical Trials
• Group sequential designs using both type I and type II error probability spending functions
• Group-Sequential Analysis Incorporating Covariate Information
• Point and interval estimation following a sequential clinical trial
• Point estimation for adaptive trial designs. I: A methodological review
• Semiparametric Efficiency and Its Implication on the Design and Analysis of Group-Sequential Studies
• Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials

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