HCTDesign

MaRDI QIDQ89009CRANFDO

Authors Tushar Patni, Yimei Li, Jianrong Wu, Arzu Onar-thomas

Last update 20 October 2025

Copyright license GNU General Public License, version 3.0

Software version identifier 0.7.2, 0.7.0, 0.7.1, 0.7.3, PACKAGES.rds, 0.7.4

Description

It provides functions to design historical controlled trials with survival outcome by group sequential method. The options for interim look boundaries are efficacy only, efficacy & futility or futility only. It also provides the function to monitor the trial for any unplanned look. The package is based on Jianrong Wu, Xiaoping Xiong (2016) <doi:10.1002/pst.1756> and Jianrong Wu, Yimei Li (2020) <doi:10.1080/10543406.2019.1684305>.

Cites work

• Group sequential design for historical control trials using error spending functions
• Survival trial design and monitoring using historical controls

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