High dimensional single-index Bayesian modeling of brain atrophy

DOI10.1214/19-BA1186MaRDI QIDQ2057356zbMATH OpenFDO

Authors Arkaprava Roy, Kingshuk Roy Choudhury, Subhashis Ghosal

Publication date 6 December 2021

Published in Bayesian Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1712.06743, https://projecteuclid.org/euclid.ba/1572858052

zbMATH Keywords

ADNIBayesiangenome-wide association study (GWAS)Hamiltonian Monte Carlohigh-dimensional datasingle-index modelspike-and-slab prior

Mathematics Subject Classification ID

Estimation in multivariate analysis (62H12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Monte Carlo methods (65C05)

Abstract: We propose a model of brain atrophy as a function of high-dimensional genetic information and low dimensional covariates such as gender, age, APOE gene, and disease status. A nonparametric single-index Bayesian model of high dimension is proposed to model the relationship with B-spline series prior on the unknown functions and Dirichlet process scale mixture of centered normal prior on the distributions of the random effects. The posterior rate of contraction without the random effect is established for a fixed number of regions and time points with increasing sample size. We implement an efficient computation algorithm through a Hamiltonian Monte Carlo (HMC) algorithm. The performance of the proposed Bayesian method is compared with the corresponding least square estimator in the linear model with horseshoe prior, LASSO and SCAD penalization on the high-dimensional covariates. The proposed Bayesian method is applied to a dataset on volumes of brain regions recorded over multiple visits of 748 individuals using 620,901 SNPs and 6 other covariates for each individual, to identify factors associated with brain atrophy.

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Cited in

(6)

• Time-varying auto-regressive models for count time-series
• A Bayesian Nonparametric Regression Model With Normalized Weights: A Study of Hippocampal Atrophy in Alzheimer’s Disease
• A Bayesian latent spatial model for mapping the cortical signature of progression to Alzheimer's disease
• Bayesian monotone single-index quantile regression model with bounded response and misaligned functional covariates
• Multivariate Gaussian RBF-net for smooth function estimation and variable selection
• Rates of convergence of the constrained least squares estimator in high-dimensional monotone single-index models

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