Hopf bifurcation analysis of pathogen-immune interaction dynamics with delay kernel

DOI10.1051/MMNP:2008010MaRDI QIDQ2788439zbMATH OpenOpenAlexFDO

Authors Mihaela Neamtu, L. Buliga, F. R. Horhat, Dumitru Opris

Publication date 19 February 2016

Published in Mathematical Modelling of Natural Phenomena (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/math/0610690

zbMATH Keywords

delay differential equationHopf bifurcationpathogen-immune interactionstability

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Periodic solutions to ordinary differential equations (34C25) Epidemiology (92D30)

Abstract: The aim of this paper is to study the steady states of the mathematical models with delay kernels which describe pathogen-immune dynamics of many kinds of infectious diseases. In the study of mathematical models of infectious diseases it is important to predict whether the infection disappears or the pathogens persist. The delay kernel is described by the memory function that reflects the influence of the past density of pathogen in the blood. By using the coefficient of kernel k, as a bifurcation parameter, the models are found to undergo a sequence of Hopf bifurcation. The direction and the stability criteria of bifurcation periodic solutions are obtained by applying the normal form theory and the center manifold theorems. Some numerical simulation examples for justifying the theoretical results are also given.

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Cites work

• A model of HIV-1 pathogenesis that includes an intracellular delay
• Complex dynamic behavior in a viral model with delayed immune response
• Hopf bifurcation and chaos analysis of Chen's system with distributed delays
• scientific article; zbMATH DE number 3743640 (Why is no real title available?)
• Mathematical analysis of delay differential equation models of HIV-1 infection
• Mathematical Analysis of HIV-1 Dynamics in Vivo
• Nonlinear oscillations in models of immune responses to persistent viruses
• Stability analysis of pathogen-immune interaction dynamics

Cited in

(4)

• Numerical bifurcation analysis of immunological models with time delays
• Hopf and Generalized Hopf Bifurcations in a Recurrent Autoimmune Disease Model
• Hopf bifurcation analysis of immune response against pathogens interaction dynamics with delays
• Hopf bifurcation analysis of immune response against pathogens interaction dynamics with delay kernel

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