Horizontal gene transfer: numerical comparison between stochastic and deterministic approaches

DOI10.1051/PROC/202067009MaRDI QIDQ3300120zbMATH OpenOpenAlexFDO

Authors Vincent Calvez, Susely Figueroa Iglesias, Hélène Hivert, Sylvie Méléard, Anna Melnykova, Samuel Nordmann

Publication date 27 July 2020

Published in ESAIM: Proceedings and Surveys (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1906.11679

zbMATH Keywords

evolution dynamicsHamilton-Jacobi equationhorizontal gene transferintegro-differential equationsresistance to antibioticsstochastic individual-based models

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Genetics and epigenetics (92D10) Problems related to evolution (92D15) Population dynamics (general) (92D25)

Abstract: Horizontal gene Transfer (HT) denotes the transmission of genetic material between two living organisms, while the vertical transmission refers to a DNA transfer from parents to their offspring. Consistent experimental evidence report that this phenomenon plays an essential role in the evolution of certain bacterias. In particular, HT is believed to be the main instrument of developing the antibiotic resistance. In this work, we consider several models which describe this phenomenon: a stochastic jump process (individual-based) and the deterministic nonlinear integrod-ifferential equation obtained as a limit for large populations. We also consider a Hamilton-Jacobi equation, obtained as a limit of the deterministic model under the assumption of small mutations. The goal of this paper is to compare these models with the help of numerical simulations. More specifically, our goal is to understand to which extent the Hamilton-Jacobi model reproduces the qualitative behavior of the stochastic model and the phenomenon of evolutionary rescue in particular.

Recommendations

• Stochastic analysis of emergence of evolutionary cyclic behavior in population dynamics with transfer
• Towards a quantitative understanding of horizontal gene transfer: a kinetic model
• Stochastic dynamics for adaptation and evolution of microorganisms
• A kinetic model for horizontal transfer and bacterial antibiotic resistance
• Within-host bacterial growth dynamics with both mutation and horizontal gene transfer

Cited in

(11)

• Towards a quantitative understanding of horizontal gene transfer: a kinetic model
• Current views of evolution: on the role of horizontal gene transfer
• scientific article; zbMATH DE number 5888322 (Why is no real title available?)
• The effect of competition and horizontal trait inheritance on invasion, fixation, and polymorphism
• Fixation probability of mobile genetic elements such as plasmids
• Statistical mechanics of horizontal gene transfer in evolutionary ecology
• Measure framework for the pure selection equation: global well posedness and numerical investigations
• Filling the gap between individual-based evolutionary models and Hamilton-Jacobi equations
• Concentration in Lotka-Volterra parabolic equations: an asymptotic-preserving scheme
• Impact of the horizontal gene transfer on the evolutionary equilibria of a population
• A Hamilton-Jacobi approach for the evolutionary dynamics of a model with gene transfer: characterizing monomorphic dynamics for non-concave fitness functions

This page was built for publication: Horizontal gene transfer: numerical comparison between stochastic and deterministic approaches

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q3300120)