Hybrid PDE ODE SEIR model

hybrid model combining PDEs and ODEs

mathematical model

MaRDI QIDQ6675146FDOCommunityMathModDB

Description

Hybrid model combining the PDE model and ODe model, by segmenting the modeling domain into a PDE part and an ODE part.

Contained entities

fraction of population density of exposed formulation	$e(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_e^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$e(x,0)$ represents fraction of population density of exposed
	$w_e^{(\tilde{l})}$ represents density fraction coefficient
integral of the population density fraction of susceptibles (initial condition)	${\int }_{{\mathrm{\Omega }}^{(l)}}s(x,0)n(x)dx={\widehat{𝒩}}_l-(1+{\mathrm{\Sigma }}_{ℰ}){\widehat{ℐ}}^{(l)}-{\widehat{ℛ}}^{(l)}$	initial condition
	${\mathrm{\Sigma }}_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	${\widehat{𝒩}}_l$ represents total population size
	${\widehat{ℛ}}^{(l)}$ represents number of removed individuals
	$n(x)$ represents total population density
	$s(x,0)$ represents fraction of population density of susceptibles
integral of the population density fraction of infectious (initial condition)	${\int }_{{\mathrm{\Omega }}^{(l)}}i(x,0)n(x)dx={\widehat{ℐ}}^{(l)}$	initial condition
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	$i(x,0)$ represents fraction of population density of infectious
	$n(x)$ represents total population density
integral of the population density fraction of exposed (initial condition)	${\int }_{{\mathrm{\Omega }}^{(l)}}e(x,0)n(x)dx={\mathrm{\Sigma }}_{ℰ}{\widehat{ℐ}}^{(l)}$	initial condition
	${\mathrm{\Sigma }}_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	$e(x,0)$ represents fraction of population density of exposed
	$n(x)$ represents total population density
total population density formulation	$n(x)\equiv \sum _{\tilde{l}=1}^{\tilde{L}}{w}_n^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$n(x)$ represents total population density
	$w_n^{(\tilde{l})}$ represents density fraction coefficient
integral of the total population density (initial condition)	${\int }_{{\mathrm{\Omega }}^{(l)}}n(x)dx={\widehat{𝒩}}_l$	initial condition
	${\widehat{𝒩}}_l$ represents total population size
	$n(x)$ represents total population density
Neumann boundary condition (SEIR model)	$s+e+i+r=1$	boundary condition
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
Allee effect	$1-\frac{A}{n+n_0}\ge \frac{1}{3}$	boundary condition
	$A$ represents Allee threshold
	$n$ represents population density
SEIR epidemiological ODE model
SEIR epidemiological PDE model
continuity of densities condition	$\begin{array}{cc}& s_1=s_2\\ & e_1=e_2\\ & i_1=i_2\\ & r_1=r_2\end{array}$	initial condition
	$e_1$ represents fraction of population density of exposed in the PDE region
	$e_2$ represents fraction of population density of exposed in the ODE region
	$i_1$ represents fraction of population density of infectious in the PDE region
	$i_2$ represents fraction of population density of infectious in the ODE region
	$r_1$ represents fraction of population density of removed in the PDE region
	$r_2$ represents fraction of population density of removed in the ODE region
	$s_1$ represents fraction of population density of susceptibles in the PDE region
	$s_2$ represents fraction of population density of susceptibles in the ODE region
SEIR derivative relation	${\nu }^{T}D\mathrm{\nabla }s={\nu }^{T}D\mathrm{\nabla }e={\nu }^{T}D\mathrm{\nabla }i={\nu }^{T}D\mathrm{\nabla }r=0$
	$D$ represents diffusion coefficient for SEIR model
	$\nu$ represents unit outer normal vector
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
rate of change of population density fraction of removed PDE	${\partial }_{t}r=\mathrm{div}(D\mathrm{\nabla }r)+{\varphi }_{i}i+{\varphi }_{e}e$
	$D$ represents diffusion coefficient for SEIR model
	${\varphi }_e$ represents asymptomatic recovery rate
	${\varphi }_i$ represents infected recovery rate
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$t$ represents time
Homogeneous Neumann Boundary Conditions	${\nu }^{T}D\mathrm{\nabla }s={\nu }^{T}D\mathrm{\nabla }e={\nu }^{T}D\mathrm{\nabla }i={\nu }^{T}D\mathrm{\nabla }r=0$
	$D$ represents mass diffusivity
	$\nu$ represents unit normal vector
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
fraction of population density of susceptibles formulation	$s(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_s^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$s(x,0)$ represents fraction of population density of susceptibles
	$w_s^{(\tilde{l})}$ represents density fraction coefficient
fraction of population density of infectious formulation	$i(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_i^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$i(x,0)$ represents fraction of population density of infectious
	$w_i^{(\tilde{l})}$ represents density fraction coefficient
rate of change of population density fraction of susceptibles PDE	${\partial }_{t}s=\mathrm{div}(D\mathrm{\nabla }s)-(1-\frac{A}{n+n_0})s({\beta }_{e}e+{\beta }_{i}i)$
	$A$ represents Allee threshold
	$D$ represents diffusion coefficient for SEIR model
	${\beta }_e$ represents asymptomatic infection rate
	${\beta }_i$ represents symptomatic infection rate
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$n$ represents population density
	$s$ represents fraction of population density of susceptibles
	$t$ represents time
isotropic Gaussian function formulation	$G^{(l)}(x)\equiv \frac{1}{2\pi {\sigma }^2}\text{exp}(-\frac{||x-x_0^{(l)}|{|}^2}{2{\sigma }^2})$
	$G^{(l)}(x)$ represents isotropic Gaussian function
	$\pi$ represents Pi
	$\sigma$ represents variance
	$x_0^{(l)}$ represents center of province
number of susceptible individuals formulation	${\widehat{𝒮}}^{(l)}={\widehat{𝒩}}^{(l)}-(1+{\mathrm{\Sigma }}_{ℰ}){\widehat{ℐ}}^{(l)}-{\widehat{ℛ}}^{(l)}$
	${\mathrm{\Sigma }}_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	${\widehat{𝒩}}^{(l)}$ represents total population size
	${\widehat{ℛ}}^{(l)}$ represents number of removed individuals
	${\widehat{𝒮}}^{(l)}$ represents number of susceptible individuals
number of exposed individuals formulation	${\widehat{ℰ}}^{(l)}={\mathrm{\Sigma }}_{ℰ}{\widehat{ℐ}}^{(l)}$
	${\mathrm{\Sigma }}_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℰ}}^{(l)}$ represents number of exposed individuals
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
rate of change of population density fraction of infectious PDE	${\partial }_{t}i=\mathrm{div}(D\mathrm{\nabla }i)+\sigma e-{\varphi }_{i}i$
	$D$ represents diffusion coefficient for SEIR model
	${\varphi }_i$ represents infected recovery rate
	$\sigma$ represents rate of becoming infectious
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$t$ represents time
rate of change of population density fraction of exposed PDE	${\partial }_{t}e=\mathrm{div}(D\mathrm{\nabla }e)+(1-\frac{A}{n+n_0})s({\beta }_{e}e+{\beta }_{i}i)-\sigma e-{\varphi }_{e}e$
	$A$ represents Allee threshold
	$D$ represents diffusion coefficient for SEIR model
	${\beta }_e$ represents asymptomatic infection rate
	${\beta }_i$ represents symptomatic infection rate
	${\varphi }_e$ represents asymptomatic recovery rate
	$\sigma$ represents rate of becoming infectious
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$n$ represents population density
	$s$ represents fraction of population density of susceptibles
	$t$ represents time
continuity of fluxes condition	${\nu }_1^{T}D\mathrm{\nabla }{s}_1={\nu }_1^{T}D\mathrm{\nabla }{e}_1={\nu }_1^{T}D\mathrm{\nabla }{i}_1={\nu }_1^{T}D\mathrm{\nabla }{r}_1=0$	initial condition
	$D$ represents mass diffusivity
	${\nu }_1$ represents unit normal vector
	$e_1$ represents fraction of population density of exposed in the PDE region
	$i_1$ represents fraction of population density of infectious in the PDE region
	$r_1$ represents fraction of population density of removed in the PDE region
	$s_1$ represents fraction of population density of susceptibles in the PDE region

Further links

Item	Property
spreading of infectious diseases	modelled by

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