Identifying intergenerational patterns of correlated methylation sites

DOI10.1214/21-AOAS1511MaRDI QIDQ2135376zbMATH OpenOpenAlexFDO

Authors Xichen Mou, Hongmei Zhang, S. Hasan Arshad

Publication date 6 May 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1214/21-aoas1511

zbMATH Keywords

clusteringDNA methylationEM algorithmgeneralized beta distribution

Mathematics Subject Classification ID

Classification and discrimination; cluster analysis (statistical aspects) (62H30) Applications of statistics to biology and medical sciences; meta analysis (62P10) Protein sequences, DNA sequences (92D20)

Recommendations

• Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression
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• Incorporating genomic annotation into a hidden Markov model for DNA methylation tiling array data
• A Bayesian hidden Markov model for detecting differentially methylated regions
• Statistical inference of transmission fidelity of DNA methylation patterns over somatic cell divisions in mammals

Cites work

• Adjusting batch effects in microarray expression data using empirical Bayes methods
• Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression
• The Clustering of Regression Models Method with Applications in Gene Expression Data
• The stochastic EM algorithm: Estimation and asymptotic results

Cited in

(2)

• Identifying heterogeneous transgenerational DNA methylation sites via clustering in beta regression
• Epigenetic profiles reveal that ADCYAP1 serves as key molecule in gestational diabetes mellitus

Describes a project that uses

Uses Software

• IMA
• Minfi
• Bioconductor

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