immunarch

Authors Vadim I. Nazarov, Vasily O. Tsvetkov, Eugene Rumynskiy, Aleksandr A. Popov, Ivan Balashov, Maria Samokhina

Last update 14 October 2025

Software version identifier 0.6.4, 0.6.5, 0.6.6, 0.6.7, 0.6.8, 0.6.9, 0.7.0, 0.8.0, 0.9.0, PACKAGES.rds, 0.9.1, 0.10.3

Description

A comprehensive analytics framework for building reproducible pipelines on T-cell and B-cell immune receptor repertoire data. Delivers multi-modal immune profiling (bulk, single-cell, CITE-seq/AbSeq, spatial, immunogenicity data), feature engineering (ML-ready feature tables and matrices), and biomarker discovery workflows (cohort comparisons, longitudinal tracking, repertoire similarity, enrichment). Provides a user-friendly interface to widely used AIRR methods — clonality/diversity, V(D)J usage, similarity, annotation, tracking, and many more. Think Scanpy or Seurat, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data. A successor to our previously published "tcR" R package (Nazarov 2015).

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