Improved pharmacovigilance signal detection using Bayesian generalized linear mixed models

DOI10.1002/SIM.70086MaRDI QIDQ6907449zbMATH OpenFDO

Authors Paloma Hauser, Xianming Tan, Fang Chen, Joseph G. Ibrahim

Publication date 1 November 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.70086

zbMATH Keywords

generalized linear mixed modelshigh-dimensional datalow-rank approximationMCMCsignal detectionVAERS

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A likelihood ratio test based method for signal detection with application to FDA's drug safety data
• Accounting for Multiplicities in Assessing Drug Safety: A Three-Level Hierarchical Mixture Model
• Bayesian generalized linear low rank regression models for the detection of vaccine-adverse event associations
• Bayesian generalized low rank regression models for neuroimaging phenotypes and genetic markers
• Extended multi-item gamma Poisson shrinker methods based on the zero-inflated Poisson model for postmarket drug safety surveillance
• Mining adverse events in large frequency tables with ontology, with an application to the vaccine adverse event reporting system
• Multivariate reduced-rank regression
• Optimal scaling for partially updating MCMC algorithms
• Reduced rank stochastic regression with a sparse singular value decomposition
• Sparse Bayesian infinite factor models
• Statistical analysis of factor models of high dimension
• The spike-and-slab LASSO

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