Inference for multimarker adaptive enrichment trials

DOI10.1002/SIM.7422MaRDI QIDQ6996105zbMATH OpenFDO

Authors Richard Simon, Noah Simon

Publication date 16 April 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.7422

zbMATH Keywords

adaptive clinical trialsbiomarkerenrichmentresampling

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• Bootstrap corrections of treatment effect estimates following selection
• Gene expression analysis with the parametric bootstrap
• Group sequential enrichment design incorporating subgroup selection
• Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment

Cited in

(1)

• Auxiliary variable-enriched biomarker-stratified design

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