CytOpT (Q115103)
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Optimal Transport for Gating Transfer in Cytometry Data with Domain Adaptation
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | CytOpT |
Optimal Transport for Gating Transfer in Cytometry Data with Domain Adaptation |
Statements
expanded from: GPL (≥ 2) (English)
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Paul Freulon
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Kalidou Ba
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1 April 2025
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Supervised learning from a source distribution (with known segmentation into cell sub-populations) to fit a target distribution with unknown segmentation. It relies regularized optimal transport to directly estimate the different cell population proportions from a biological sample characterized with flow cytometry measurements. It is based on the regularized Wasserstein metric to compare cytometry measurements from different samples, thus accounting for possible mis-alignment of a given cell population across sample (due to technical variability from the technology of measurements). Supervised learning technique based on the Wasserstein metric that is used to estimate an optimal re-weighting of class proportions in a mixture model Details are presented in Freulon P, Bigot J and Hejblum BP (2023) <doi:10.1214/22-AOAS1660>.
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