ondisc (Q129145)
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Algorithms and Data Structures for Large Single-Cell Expression Matrices
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
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| English | ondisc |
Algorithms and Data Structures for Large Single-Cell Expression Matrices |
Statements
17 June 2026
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Single-cell datasets are growing in size, posing challenges as well as opportunities for genomics researchers. 'ondisc' is an R package that facilitates analysis of large-scale single-cell data out-of-core on a laptop or distributed across tens to hundreds of processors on a cluster or cloud. In both of these settings, 'ondisc' requires only a few gigabytes of memory, even if the input data are tens of gigabytes in size. 'ondisc' mainly is oriented toward single-cell CRISPR screen analysis, but also can be used for single-cell differential expression and single-cell co-expression analyses. 'ondisc' is powered by several new, efficient algorithms for manipulating and querying large, sparse expression matrices.
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Eugene Katsevich
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