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      24 November 2008
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      quantitative trait loci
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      restricted maximum likelihood
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      average information matrix
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      identity-by-descent matrix
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      variance components
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      Newton-type optimization methods
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      active-set method
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      inverse BFGS formula
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      Hessian approximation
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      Broyden-Fletcher-Goldfarb-Shanno (BFGS)
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