LOCOM2

MaRDI QIDQ7378287CRANFDO

Authors Yi-Juan Hu

Last update 29 October 2026

Copyright license GNU General Public License, version 2.0, GNU General Public License, version 3.0

Software version identifier 1.0, PACKAGES.rds, 1.1

Description

Testing differential abundance at individual taxa and in a whole microbial community. The tests are based on the log-ratio of relative abundances. The tests accommodate continuous, discrete (binary, categorical), and multivariate traits, and allow adjustment of confounders. For more details see He (2026) <doi:10.64898/2026.04.07.716976>. This package also includes the 'com2seq' function that combines two sequencing datasets (e.g., from 16S marker-gene and shotgun sequencing) for integrative analysis of differential abundance. For more details see <doi:10.1080/01621459.2025.2516205>.

Cites work

• Integrative Analysis of Microbial 16S Gene and Shotgun Metagenomic Sequencing Data Improves Statistical Efficiency in Testing Differential Abundance
• LOCOM2: Robust Differential Abundance Analysis for Microbiome Data

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