LTFGRS

MaRDI QIDQ7383662CRANFDO

Authors Emil Michael Pedersen, Jette Steinbach, Morten Dybdahl Krebs

Last update 28 August 2025

Copyright license GNU General Public License

Software version identifier 1.0.0, PACKAGES.rds, 1.0.1

Description

Implementation of several phenotype-based family genetic risk scores with unified input data and data preparation functions to help facilitate the required data preparation and management. The implemented family genetic risk scores are the extended liability threshold model conditional on family history from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>, Pearson-Aitken Family Genetic Risk Scores from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>, and family genetic risk score from Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.

Cites work

• Accounting for age of onset and family history improves power in genome-wide association studies
• Family Genetic Risk Scores and the Genetic Architecture of Major Affective and Psychotic Disorders in a Swedish National Sample
• Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression

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