Learning Non-monotone Optimal Individualized Treatment Regimes

DOI10.5705/SS.202021.0339MaRDI QIDQ6185134zbMATH OpenFDO

Authors Trinetri Ghosh, Yanyuan Ma, Wensheng Zhu, Yuanjia Wang

Publication date 29 January 2024

Published in STATISTICA SINICA (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2109.12215

zbMATH Keywords

double- and multi-robustoptimal treatment regimespropensity scorevalue function

Mathematics Subject Classification ID

Statistics (62-XX)

Abstract: We propose a new modeling and estimation approach to select the optimal treatment regime from different options through constructing a robust estimating equation. The method is protected against misspecification of the propensity score model, the outcome regression model for the non-treated group, or the potential non-monotonic treatment difference model. Our method also allows residual errors to depend on covariates. A single index structure is incorporated to facilitate the nonparametric estimation of the treatment difference. We then identify the optimal treatment through maximizing the value function. Theoretical properties of the treatment assignment strategy are established. We illustrate the performance and effectiveness of our proposed estimators through extensive simulation studies and a real dataset on the effect of maternal smoking on baby birth weight.

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