Likelihood-based missing data analysis in crossover trials

DOI10.1214/23-BJPS570MaRDI QIDQ6178485zbMATH OpenOpenAlexFDO

Authors Savita Pareek, Kalyan Das, Siuli Mukhopadhyay

Publication date 1 September 2023

Published in Brazilian Journal of Probability and Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2103.06567

zbMATH Keywords

crossover trialsMCEM likelihood ratio testsMonte Carlo EM algorithm

Mathematics Subject Classification ID

Statistics (62-XX) Biology and other natural sciences (92-XX)

Abstract: A multivariate mixed-effects model seems to be the most appropriate for gene expression data collected in a crossover trial. It is, however, difficult to obtain reliable results using standard statistical inference when some responses are missing. Particularly for crossover studies, missingness is a serious concern as the trial requires a small number of participants. A Monte Carlo EM (MCEM)-based technique was adopted to deal with this situation. In addition to estimation, MCEM likelihood ratio tests (LRTs) are developed to test fixed effects in crossover models with missing data. Intensive simulation studies were conducted prior to analyzing gene expression data.

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Cited in

(5)

• Likelihood Methods for Missing Covariate Data in Highly Stratified Studies
• Universally optimal multivariate crossover designs
• Efficient designs for multivariate crossover trials
• Likelihood-based inference for skewed responses in a crossover trial setup
• Ternary designs enabling efficient estimation of residual effects

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