Likelihood for Generally Coarsened Observations from Multistate or Counting Process Models
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Abstract: We consider first the mixed discrete-continuous scheme of observation in multistate models; this is a classical pattern in epidemiology because very often clinical status is assessed at discrete visit times while times of death or other events are observed exactly. A heuristic likelihood can be written for such models, at least for Markov models; however, a formal proof is not easy and has not been given yet. We present a general class of possibly non-Markov multistate models which can be represented naturally as multivariate counting processes. We give a rigorous derivation of the likelihood based on applying Jacod's formula for the full likelihood and taking conditional expectation for the observed likelihood. A local description of the likelihood allows us to extend the result to a more general coarsening observation scheme proposed by Commenges & G'egout-Petit. The approach is illustrated by considering models for dementia, institutionalization and death.
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Cited in
(8)- Dealing with death when studying disease or physiological marker: the stochastic system approach to causality
- A general dynamical statistical model with causal interpretation
- Multiple imputation for estimating the risk of developing dementia and its impact on survival
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- Estimating life expectancy of demented and institutionalized subjects from interval-censored observations of a multi-state model
- Measuring mortality heterogeneity with multi-state models and interval-censored data
- Quantifying the association between progression-free survival and overall survival in oncology trials using Kendall's
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