Likelihood ratio based tests for longitudinal drug safety data

DOI10.1002/SIM.6103MaRDI QIDQ6929761zbMATH OpenFDO

Authors Lan Huang, Jyoti N. Zalkikar, Ram C. Tiwari

Publication date 16 September 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.6103

zbMATH Keywords

active surveillancedrug exposurelongitudinal methodsafety surveillancesequential method

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A likelihood ratio test based method for signal detection with application to FDA's drug safety data
• A maximized sequential probability ratio test for drug and vaccine safety surveillance
• Detecting multiple change points in piecewise constant hazard functions
• Discrete Sequential Boundaries for Clinical Trials
• scientific article; zbMATH DE number 1348603 (Why is no real title available?)
• Modeling Reporting Delays and Reporting Corrections in Cancer Registry Data

Cited in

(4)

• Signal detection in FDA AERS database using Dirichlet process
• A nonparametric method to detect increased frequencies of adverse drug reactions over time
• Mixture drug-count response model for the high-dimensional drug combinatory effect on myopathy
• A nonparametric Bayesian local-global model for enhanced adverse event signal detection in spontaneous reporting system data

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