MGDrivE

MaRDI QIDQ134177CRANFDO

Authors Héctor Manuel Sánchez Castellanos, Jared Bennett, John M. Marshall, Sean Wu

Last update 5 September 2025

Copyright license GNU General Public License, version 3.0

Software version identifier 1.6.0, 1.0.0, 1.1.0, 1.5.0, PACKAGES.rds, 1.6.2

Description

Provides a model designed to be a reliable testbed where various gene drive interventions for mosquito-borne diseases control. It is being developed to accommodate the use of various mosquito-specific gene drive systems within a population dynamics framework that allows migration of individuals between patches in landscape. Previous work developing the population dynamics can be found in Deredec et al. (2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>, and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017) <doi:10.1038/s41598-017-02744-7>.

Cites work

• Application of the lumped age-class technique to studying the dynamics of malaria-mosquito-human interactions
• Overcoming evolved resistance to population-suppressing homing-based gene drives
• Requirements for effective malaria control with homing endonuclease genes

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