MIML
Imputes missing biomarker measurements in a wide longitudinal serum panel with gradient-boosted decision trees, groups the completed panel by Bayesian consensus clustering, and compares the resulting patient subgroups by Kaplan-Meier, log-rank and Cox analysis. The imputation learner is described in Ke et al. (2017) <https://papers.nips.cc/paper/6907-lightgbm-a-highly-efficient-gradient-boosting-decision-tree> and the clustering method in Lock and Dunson (2013) <doi:10.1093/bioinformatics/btt425>. Imputed values are conditional-mean predictions, so the procedure is a machine-learning single imputation; the completions carry no between-imputation variance and must not be pooled by Rubin's rules. Two panels from Gene Expression Omnibus accession 'GSE65622' are included, one for each survival endpoint.
This page was built for software: MIML
