MRPC

MaRDI QIDQ36429swMATHCRANFDO

Authors Audrey Qiuyan Fu, Md Bahadur Badsha

Last update 13 September 2025

Copyright license GNU General Public License, version 2.0, GNU General Public License, version 3.0

Software version identifier 3.1.0, 1.0.0, 2.0.0, 2.1.0, 2.2.0, 2.2.1, 2.2.2, 2.3.0, 2.3.1, 3.0.0, PACKAGES.rds, 3.2.0

Official website https://arxiv.org/abs/1806.01899

Source code repository https://github.com/audreyqyfu/mrpc

Description

A PC Algorithm with the Principle of Mendelian Randomization. This package implements the MRPC (PC with the principle of Mendelian randomization) algorithm to infer causal graphs. It also contains functions to simulate data under a certain topology, to visualize a graph in different ways, and to compare graphs and quantify the differences. See Badsha and Fu (2019) <doi:10.3389/fgene.2019.00460>, Badsha, Martin and Fu (2021) <doi:10.3389/fgene.2021.651812>, Kvamme and Badsha, et al. (2025) <doi:10.1093/genetics/iyaf064>.

Cites work

• Causal network inference of cis- and trans-gene regulation of expression quantitative trait loci across human tissues
• Learning Causal Biological Networks With the Principle of Mendelian Randomization
• MRPC: An R Package for Inference of Causal Graphs

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