Mathematical modeling of antigenicity for HIV dynamics
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Abstract: This contribution is devoted to a new model of HIV multiplication motivated by the patent of one of the authors. We take into account the antigenic diversity through what we define "antigenicity", whether of the virus or of the adapted lymphocytes. We model the interaction of the immune system and the viral strains by two processes. On the one hand, the presence of a given viral quasi-species generates antigenically adapted lymphocytes. On the other hand, the lymphocytes kill only viruses for which they have been designed. We consider also the mutation and multiplication of the virus. An original infection term is derived. So as to compare our system of differential equations with well-known models, we study some of them and compare their predictions to ours in the reduced case of only one antigenicity. In this particular case, our model does not yield any major qualitative difference. We prove mathematically that, in this case, our model is biologically consistent (positive fields) and has a unique continuous solution for long time evolution. In conclusion, this model improves the ability to simulate more advanced phases of the disease.
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Cites work
- scientific article; zbMATH DE number 3489473 (Why is no real title available?)
- scientific article; zbMATH DE number 2038872 (Why is no real title available?)
- scientific article; zbMATH DE number 1564073 (Why is no real title available?)
- Comparison of three kinetic models of HIV-1 infection: implications for optimization of treatment
- Global Stability of Steady Solutions for a Model in Virus Dynamics
- HIV-1 infection and low steady state viral loads
- Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus?
- Mathematical Analysis of HIV-1 Dynamics in Vivo
- Mathematical analysis of the global dynamics of a model for HIV infection of CD4\(^{+}\) T cells
- Model selection and mixed-effects modeling of HIV infection dynamics
- Practical identifiability of HIV dynamics models
- Virus Dynamics: A Global Analysis
Cited in
(12)- Mathematical model of multivalent virus-antibody complex formation in humans following acute and chronic HIV infections
- Mathematical modelling of HIV within-host evolution
- On the antigenic diversity threshold model for AIDS
- A mathematical model of HIV infection: Simulating T4, T8 macrophages, antibody, and virus via specific anti-HIV response in the presence of adaptation and tropism
- On the numerical simulation of a class of HIV models
- Mathematical modelling of the within-host HIV quasispecies dynamics in response to antiviral treatment
- A Mathematical Model of Continuous HIV Mutations Eluding Immune Defence
- A stochastic microscopic model for the dynamics of antigenic variation
- scientific article; zbMATH DE number 727419 (Why is no real title available?)
- Mathematical analysis and clinical implications of an HIV model with adaptive immunity
- A singularly perturbed HIV model with treatment and antigenic variation
- Mathematical model for HIV dynamics in HIV-specific helper cells
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