Mathematical models of bipolar disorder
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Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Dynamical systems in biology (37N25) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Oscillation theory, zeros, disconjugacy and comparison theory for ordinary differential equations (34C10)
Abstract: We use limit cycle oscillators to model Bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about one percent of the United States adult population. We consider two nonlinear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using weakly-coupled, weakly-damped harmonic oscillators. We discuss how the proposed models can be used as a framework for refined models that incorporate additional biological data. We conclude with a discussion of possible generalizations of our work, as there are several biologically-motivated extensions that can be readily incorporated into the series of models presented here.
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Cites work
- scientific article; zbMATH DE number 3961414 (Why is no real title available?)
- scientific article; zbMATH DE number 712314 (Why is no real title available?)
- Bifurcation analysis of parametrically excited bipolar disorder model
- Comment on ``Bifurcation analysis of parametrically excited bipolar disorder model
- Dynamics of two van der Pol oscillators coupled via a bath
- Mathematical models of bipolar disorder
- The dynamics of two coupled van der Pol oscillators with delay coupling
Cited in
(11)- Evolutionary stochastic model of the dynamics of psycho-emotional states in affective disorders
- Bipolar comparison
- A brief note on recurrence quantification analysis of bipolar disorder performed by using a van der Pol oscillator model
- Synchronization of chaotic and nonchaotic oscillators: Application to bipolar disorder
- A limit cycle oscillator model for cycling mood variations of bipolar disorder patients derived from cellular biochemical reaction equations
- Comment on ``Bifurcation analysis of parametrically excited bipolar disorder model
- Mathematical models of bipolar disorder
- A modified second-order Collatz equation as a mathematical model of bipolar disorder
- Bifurcation analysis of parametrically excited bipolar disorder model
- Monoamine neurotransmitters and mood swings: a dynamical systems approach
- Towards a complex system understanding of bipolar disorder: a map based model of a complex winnerless competition
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