hybrid PDE ODE SEIR model

Community: MathModDB

mathematical model

Available identifiers

MaRDI QIDQ6675146 FDOQ6675146

hybrid model combining PDEs and ODEs

Description

Hybrid model combining the PDE model and ODe model, by segmenting the modeling domain into a PDE part and an ODE part.

List of contained entities

Allee effect	$1-\frac{A}{n+n_0}\ge \frac{1}{3}$	boundary condition
	$A$ represents Allee threshold
	$n$ represents population density
Homogeneous Neumann Boundary Conditions	${\nu }^{T}D\mathrm{\nabla }s={\nu }^{T}D\mathrm{\nabla }e={\nu }^{T}D\mathrm{\nabla }i={\nu }^{T}D\mathrm{\nabla }r=0$
	$D$ represents mass diffusivity
	$\nu$ represents unit normal vector
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
Neumann boundary condition (SEIR model)	$s+e+i+r=1$	boundary condition
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
SEIR derivative relation	${\nu }^{T}D\mathrm{\nabla }s={\nu }^{T}D\mathrm{\nabla }e={\nu }^{T}D\mathrm{\nabla }i={\nu }^{T}D\mathrm{\nabla }r=0$
	$D$ represents diffusion coefficient for SEIR model
	$\nu$ represents unit outer normal vector
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$s$ represents fraction of population density of susceptibles
SEIR epidemiological ODE model
SEIR epidemiological PDE model
continuity of densities condition	$\begin{array}{cc}& s_1=s_2\\ & e_1=e_2\\ & i_1=i_2\\ & r_1=r_2\\ \end{array}$	initial condition
	$e_1$ represents fraction of population density of exposed in the PDE region
	$e_2$ represents fraction of population density of exposed in the ODE region
	$i_1$ represents fraction of population density of infectious in the PDE region
	$i_2$ represents fraction of population density of infectious in the ODE region
	$r_1$ represents fraction of population density of removed in the PDE region
	$r_2$ represents fraction of population density of removed in the ODE region
	$s_1$ represents fraction of population density of susceptibles in the PDE region
	$s_2$ represents fraction of population density of susceptibles in the ODE region
continuity of fluxes condition	${\nu }_1^{T}D\mathrm{\nabla }{s}_1={\nu }_1^{T}D\mathrm{\nabla }{e}_1={\nu }_1^{T}D\mathrm{\nabla }{i}_1={\nu }_1^{T}D\mathrm{\nabla }{r}_1=0$	initial condition
	$D$ represents mass diffusivity
	${\nu }_1$ represents unit normal vector
	$e_1$ represents fraction of population density of exposed in the PDE region
	$i_1$ represents fraction of population density of infectious in the PDE region
	$r_1$ represents fraction of population density of removed in the PDE region
	$s_1$ represents fraction of population density of susceptibles in the PDE region
fraction of population density of exposed formulation	$e(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_e^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$e(x,0)$ represents fraction of population density of exposed
	$w_e^{(\tilde{l})}$ represents density fraction coefficient
fraction of population density of infectious formulation	$i(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_i^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$i(x,0)$ represents fraction of population density of infectious
	$w_i^{(\tilde{l})}$ represents density fraction coefficient
fraction of population density of susceptibles formulation	$s(x,0)=\sum _{\tilde{l}=1}^{\tilde{L}}{w}_s^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$s(x,0)$ represents fraction of population density of susceptibles
	$w_s^{(\tilde{l})}$ represents density fraction coefficient
integral of the population density fraction of exposed (initial condition)	$\underset{{\Omega }^{(l)}}{\int }e(x,0)n(x)dx={\Sigma }_{ℰ}{\widehat{ℐ}}^{(l)}$	initial condition
	${\Sigma }_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	$e(x,0)$ represents fraction of population density of exposed
	$n(x)$ represents total population density
integral of the population density fraction of infectious (initial condition)	$\underset{{\Omega }^{(l)}}{\int }i(x,0)n(x)dx={\widehat{ℐ}}^{(l)}$	initial condition
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	$i(x,0)$ represents fraction of population density of infectious
	$n(x)$ represents total population density
integral of the population density fraction of susceptibles (initial condition)	$\underset{{\Omega }^{(l)}}{\int }s(x,0)n(x)dx={\widehat{𝒩}}_l-(1+{\Sigma }_{ℰ}){\widehat{ℐ}}^{(l)}-{\widehat{ℛ}}^{(l)}$	initial condition
	${\Sigma }_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	${\widehat{𝒩}}_l$ represents total population size
	${\widehat{ℛ}}^{(l)}$ represents number of removed individuals
	$n(x)$ represents total population density
	$s(x,0)$ represents fraction of population density of susceptibles
integral of the total population density (initial condition)	$\underset{{\Omega }^{(l)}}{\int }n(x)dx={\widehat{𝒩}}_l$	initial condition
	${\widehat{𝒩}}_l$ represents total population size
	$n(x)$ represents total population density
isotropic Gaussian function formulation	$G^{(l)}(x)\equiv \frac{1}{2\pi {\sigma }^2}\text{exp}(-\frac{||x-x_0^{(l)}|{|}^2}{2{\sigma }^2})$
	$G^{(l)}(x)$ represents isotropic Gaussian function
	$\pi$ represents Pi
	$\sigma$ represents variance
	$x_0^{(l)}$ represents center of province
number of exposed individuals formulation	${\widehat{ℰ}}^{(l)}={\Sigma }_{ℰ}{\widehat{ℐ}}^{(l)}$
	${\Sigma }_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℰ}}^{(l)}$ represents number of exposed individuals
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
number of susceptible individuals formulation	${\widehat{𝒮}}^{(l)}={\widehat{𝒩}}^{(l)}-(1+{\Sigma }_{ℰ}){\widehat{ℐ}}^{(l)}-{\widehat{ℛ}}^{(l)}$
	${\Sigma }_{ℰ}$ represents coefficient scaling infectious to exposed
	${\widehat{ℐ}}^{(l)}$ represents number of infectious individuals
	${\widehat{𝒩}}^{(l)}$ represents total population size
	${\widehat{ℛ}}^{(l)}$ represents number of removed individuals
	${\widehat{𝒮}}^{(l)}$ represents number of individuals (susceptible)
rate of change of population density fraction of exposed PDE	${\partial }_{t}e=\mathrm{div}(D\mathrm{\nabla }e)+(1-\frac{A}{n+n_0})s({\beta }_{e}e+{\beta }_{i}i)-\sigma e-{\varphi }_{e}e$
	$A$ represents Allee threshold
	$D$ represents diffusion coefficient for SEIR model
	${\beta }_e$ represents asymptomatic infection rate
	${\beta }_i$ represents symptomatic infection rate
	${\varphi }_e$ represents asymptomatic recovery rate
	$\sigma$ represents rate of becoming infectious
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$n$ represents population density
	$s$ represents fraction of population density of susceptibles
	$t$ represents time
rate of change of population density fraction of infectious PDE	${\partial }_{t}i=\mathrm{div}(D\mathrm{\nabla }i)+\sigma e-{\varphi }_{i}i$
	$D$ represents diffusion coefficient for SEIR model
	${\varphi }_i$ represents infected recovery rate
	$\sigma$ represents rate of becoming infectious
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$t$ represents time
rate of change of population density fraction of removed PDE	${\partial }_{t}r=\mathrm{div}(D\mathrm{\nabla }r)+{\varphi }_{i}i+{\varphi }_{e}e$
	$D$ represents diffusion coefficient for SEIR model
	${\varphi }_e$ represents asymptomatic recovery rate
	${\varphi }_i$ represents infected recovery rate
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$r$ represents fraction of population density of removed
	$t$ represents time
rate of change of population density fraction of susceptibles PDE	${\partial }_{t}s=\mathrm{div}(D\mathrm{\nabla }s)-(1-\frac{A}{n+n_0})s({\beta }_{e}e+{\beta }_{i}i)$
	$A$ represents Allee threshold
	$D$ represents diffusion coefficient for SEIR model
	${\beta }_e$ represents asymptomatic infection rate
	${\beta }_i$ represents symptomatic infection rate
	$e$ represents fraction of population density of exposed
	$i$ represents fraction of population density of infectious
	$n$ represents population density
	$s$ represents fraction of population density of susceptibles
	$t$ represents time
total population density formulation	$n(x)\equiv \sum _{\tilde{l}=1}^{\tilde{L}}{w}_n^{(\tilde{l})}{G}^{(\tilde{l})}(x)$
	$G^{(\tilde{l})}(x)$ represents isotropic Gaussian function
	$n(x)$ represents total population density
	$w_n^{(\tilde{l})}$ represents density fraction coefficient

Further items linking to hybrid PDE ODE SEIR model

Item	Property
spreading of infectious diseases	modelled by

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