Bi bi reaction ordered mechanism Michaelis Menten model with products 1 and 2 (steady state assumption)

bi bi reaction Michaelis Menten model following an ordered mechanism with products 1 and 2 formulated via the steady state assumption.

Community: MathModDB

deterministic model

dimensional model

mathematical model

nonlinear model

static model

Available identifiers

MaRDI QIDQ6675340FDOQ6675340

Named after

Leonor Michaelis, Maud Menten

Contained entities

initial product 1 concentration (bi bi reaction ordered with product 1 - Michaelis Menten model)	$c_{P_1}(t=0)=c_{P_{1,0}}$	initial condition
	$c_{P_1}$ represents concentration
	$t$ represents time
initial product 2 concentration (bi bi reaction ordered with product 2 - Michaelis Menten model)	$c_{{\mathrm{P}}_2}(t=0)=c_{{\mathrm{P}}_{2,0}}$	initial condition
	$c_{P_2}$ represents concentration
	$t$ represents time
initial substrate 2 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{{\mathrm{S}}_2}(t=0)=c_{{\mathrm{S}}_{2,0}}$	initial condition
	$c_{{\mathrm{S}}_2}$ represents concentration
	$t$ represents time
initial substrate 1 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{S_1}(t=0)=c_{S_{1,0}}$	initial condition
	$c_{S_1}$ represents concentration
	$t$ represents time
law of mass action	$v=k\prod _{i=1}^n{c}_i$
	$c_i$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate
mass balance	${\delta }_t+\mathrm{\nabla }F=0$
	$t$ represents time
Michaelis Menten equation (bi bi reaction ordered with products 1 and 2 - steady state assumption)	$v_0=\frac{V_{max,f}{V}_{max,b}(c_{S_1}{c}_{S_2}-\frac{c_{P_1}{c}_{P_2}}{K_{eq}})}{V_{max,b}{K}_{i{S}_1}{K}_{S_2}+V_{max,b}{K}_{S_2}{c}_{S_1}+V_{max,b}{K}_{S_1}{c}_{S_2}+\frac{V_{max,f}{K}_{P_1}}{K_{eq}}{c}_{P_2}+\frac{V_{max,f}{K}_{P_2}}{K_{eq}}{c}_{P_1}+V_{max,b}{c}_{S_1}{c}_{S_2}+\frac{V_{max,f}{K}_{P_1}}{K_{i{S}_1}{K}_{eq}}{c}_{S_1}{c}_{P_2}+\frac{V_{max,f}}{K_{eq}}{c}_{P_1}{c}_{P_2}+\frac{V_{max,b}{K}_{S_1}}{K_{i{P}_1}}{c}_{S_1}{c}_{P_1}+\frac{V_{max,b}}{K_{i{P}_2}}{c}_{S_1}{c}_{S_2}{c}_{P_2}+\frac{V_{max,f}}{K_{i{S}_2}{K}_{eq}}{c}_{S_2}{c}_{P_1}{c}_{P_2}}$
	$K_{P_1}$ represents Michaelis constant product 1 (bi bi reaction ordered - steady state assumption)
	$K_{P_2}$ represents Michaelis constant product 2 (bi bi reaction ordered - steady state assumption)
	$K_{S_1}$ represents Michaelis constant substrate 1 (bi bi reaction ordered - steady state assumption)
	$K_{S_2}$ represents Michaelis constant substrate 2 (bi bi reaction ordered - steady state assumption)
	$K_{eq}$ represents equilibrium constant (bi bi reaction ordered - steady state assumption)
	$K_{i{P}_1}$ represents inhibition constant product 1 (bi bi reaction ordered - steady state assumption)
	$K_{i{P}_2}$ represents inhibition constant product 2 (bi bi reaction ordered - steady state assumption)
	$K_{i{S}_1}$ represents inhibition constant substrate 1 (bi bi reaction ordered - steady state assumption)
	$K_{i{S}_2}$ represents inhibition constant substrate 2 (bi bi reaction ordered - steady state assumption)
	$V_{max,b}$ represents limiting reaction rate (bi bi reaction ordered mechanism - backward)
	$V_{max,f}$ represents limiting reaction rate (bi bi reaction ordered mechanism - forward)
	$c_{P_1}$ represents product concentration
	$c_{P_2}$ represents product concentration
	$c_{S_1}$ represents substrate concentration
	$c_{S_2}$ represents substrate concentration
	$v_0$ represents initial reaction rate

Computational tasks

nonlinear parameter estimation of enzyme kinetics

Assumptions

steady state assumption

Further links

Item	Property
bi bi reaction ordered mechanism (ODE model)	specialized by
initial reaction rate of bi bi reaction following ordered mechanism with products 1 and 2	modelled by

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