bi bi reaction ordered mechanism Michaelis Menten model with products 1 and 2 (steady state assumption)

Community: MathModDB

deterministic model	dimensional model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675340

bi bi reaction Michaelis Menten model following an ordered mechanism with products 1 and 2 formulated via the steady state assumption, named after Leonor Michaelis, Maud Menten

List of contained entities

Michaelis Menten equation (bi bi reaction ordered with products 1 and 2 - steady state assumption)	$v_{0} = \frac{V_{m a x, f} V_{m a x, b} (c_{S_{1}} c_{S_{2}} - \frac{c_{P_{1}} c_{P_{2}}}{K_{e q}})}{V_{m a x, b} K_{i S_{1}} K_{S_{2}} + V_{m a x, b} K_{S_{2}} c_{S_{1}} + V_{m a x, b} K_{S_{1}} c_{S_{2}} + \frac{V_{m a x, f} K_{P_{1}}}{K_{e q}} c_{P_{2}} + \frac{V_{m a x, f} K_{P_{2}}}{K_{e q}} c_{P_{1}} + V_{m a x, b} c_{S_{1}} c_{S_{2}} + \frac{V_{m a x, f} K_{P_{1}}}{K_{i S_{1}} K_{e q}} c_{S_{1}} c_{P_{2}} + \frac{V_{m a x, f}}{K_{e q}} c_{P_{1}} c_{P_{2}} + \frac{V_{m a x, b} K_{S_{1}}}{K_{i P_{1}}} c_{S_{1}} c_{P_{1}} + \frac{V_{m a x, b}}{K_{i P_{2}}} c_{S_{1}} c_{S_{2}} c_{P_{2}} + \frac{V_{m a x, f}}{K_{i S_{2}} K_{e q}} c_{S_{2}} c_{P_{1}} c_{P_{2}}}$
	$K_{P_{1}}$ represents Michaelis constant product 1 (bi bi reaction ordered - steady state assumption)
	$K_{P_{2}}$ represents Michaelis constant product 2 (bi bi reaction ordered - steady state assumption)
	$K_{S_{1}}$ represents Michaelis constant substrate 1 (bi bi reaction ordered - steady state assumption)
	$K_{S_{2}}$ represents Michaelis constant substrate 2 (bi bi reaction ordered - steady state assumption)
	$K_{e q}$ represents equilibrium constant (bi bi reaction ordered - steady state assumption)
	$K_{i P_{1}}$ represents inhibition constant product 1 (bi bi reaction ordered - steady state assumption)
	$K_{i P_{2}}$ represents inhibition constant product 2 (bi bi reaction ordered - steady state assumption)
	$K_{i S_{1}}$ represents inhibition constant substrate 1 (bi bi reaction ordered - steady state assumption)
	$K_{i S_{2}}$ represents inhibition constant substrate 2 (bi bi reaction ordered - steady state assumption)
	$V_{m a x, b}$ represents limiting reaction rate (bi bi reaction ordered mechanism - backward)
	$V_{m a x, f}$ represents limiting reaction rate (bi bi reaction ordered mechanism - forward)
	$c_{P_{1}}$ represents product concentration
	$c_{P_{2}}$ represents product concentration
	$c_{S_{1}}$ represents substrate concentration
	$c_{S_{2}}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

initial product 1 concentration (bi bi reaction ordered with product 1 - Michaelis Menten model)	$c_{P_{1}} (t = 0) = c_{P_{1, 0}}$	initial condition
	$c_{P_{1}}$ represents concentration
	$t$ represents time

initial product 2 concentration (bi bi reaction ordered with product 2 - Michaelis Menten model)	$c_{P_{2}} (t = 0) = c_{P_{2, 0}}$	initial condition
	$c_{P_{2}}$ represents concentration
	$t$ represents time

initial substrate 1 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{S_{1}} (t = 0) = c_{S_{1, 0}}$	initial condition
	$c_{S_{1}}$ represents concentration
	$t$ represents time

initial substrate 2 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{S_{2}} (t = 0) = c_{S_{2, 0}}$	initial condition
	$c_{S_{2}}$ represents concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

mass balance	$δ_{t} + \nabla F = 0$

List of computational tasks

nonlinear parameter estimation of enzyme kinetics

List of assumptions

steady state assumption

Further items linking to bi bi reaction ordered mechanism Michaelis Menten model with products 1 and 2 (steady state assumption)

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