Bi bi reaction ordered mechanism Michaelis Menten model with products 1 and 2 and single central complex (steady state assumption)

Community: MathModDB

deterministic model	dimensional model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675341 FDOQ6675341

Named after

Leonor Michaelis, Maud Menten

Contained entities

initial substrate 1 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{S_{1}} (t = 0) = c_{S_{1, 0}}$	initial condition
	$c_{S_{1}}$ represents concentration
	$t$ represents time

initial substrate 2 concentration (bi bi reaction ordered - Michaelis Menten model)	$c_{S_{2}} (t = 0) = c_{S_{2, 0}}$	initial condition
	$c_{S_{2}}$ represents concentration
	$t$ represents time

initial product 1 concentration (bi bi reaction ordered with product 1 - Michaelis Menten model)	$c_{P_{1}} (t = 0) = c_{P_{1, 0}}$	initial condition
	$c_{P_{1}}$ represents concentration
	$t$ represents time

initial product 2 concentration (bi bi reaction ordered with product 2 - Michaelis Menten model)	$c_{P_{2}} (t = 0) = c_{P_{2, 0}}$	initial condition
	$c_{P_{2}}$ represents concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

Michaelis Menten equation (bi bi reaction ordered with products 1 and 2 and single central complex - steady state assumption)	$v_{0} = \frac{V_{1} V_{2} (c_{S_{1}} c_{S_{2}} - \frac{c_{P_{1}} c_{P_{2}}}{K_{e q}})}{V_{2} K_{i S_{1}} K_{S_{2}} + V_{2} K_{S_{2}} c_{S_{1}} + V_{2} K_{S_{1}} c_{S_{2}} + \frac{V_{1} K_{P_{1}}}{K_{e q}} c_{P_{2}} + \frac{V_{1} K_{P_{2}}}{K_{e q}} c_{P_{1}} + V_{2} c_{S_{1}} c_{S_{2}} + \frac{V_{1} K_{P_{1}}}{K_{i S_{1}} K_{e q}} c_{S_{1}} c_{P_{2}} + \frac{V_{1}}{K_{e q}} c_{P_{1}} c_{P_{2}} + \frac{V_{2} K_{S_{1}}}{K_{i P_{1}}} c_{S_{1}} c_{P_{1}} + \frac{V_{2}}{K_{i P_{2}}} c_{S_{1}} c_{S_{2}} c_{P_{2}} + \frac{V_{1}}{K_{i S_{2}} K_{e q}} c_{S_{2}} c_{P_{1}} c_{P_{2}}}$
	$K_{P_{1}}$ represents Michaelis constant
	$K_{P_{2}}$ represents Michaelis constant
	$K_{S_{1}}$ represents Michaelis constant substrate 1 (bi bi reaction ordered with single central complex - steady state assumption)
	$K_{S_{2}}$ represents Michaelis constant substrate 2 (bi bi reaction ordered with single central complex - steady state assumption)
	$K_{e q}$ represents equilibrium constant
	$K_{i P_{1}}$ represents inhibition constant
	$K_{i P_{2}}$ represents inhibition constant
	$K_{i S_{1}}$ represents inhibition constant
	$K_{i S_{2}}$ represents inhibition constant
	$V_{1}$ represents limiting reaction rate (bi bi reaction ordered mechanism with single central complex - forward)
	$V_{2}$ represents limiting reaction rate backward (bi bi reaction ordered - single central complex)
	$c_{P_{1}}$ represents concentration
	$c_{P_{2}}$ represents concentration
	$c_{S_{1}}$ represents concentration
	$c_{S_{2}}$ represents concentration
	$v_{0}$ represents reaction rate

mass balance	$δ_{t} + \nabla F = 0$
	$t$ represents time

Computational tasks

nonlinear parameter estimation of enzyme kinetics

Assumptions

steady state assumption

Further links

Item	Property
bi bi reaction ordered mechanism with single central complex (ODE model)	specialized by
initial reaction rate of bi bi reaction following ordered mechanism with products 1 and 2 and single central complex	modelled by

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