Uni uni reaction competitive complete inhibition (Michaelis Menten model without product - steady state assumption)

uni uni reaction Michaelis Menten model without product and competitive complete Inhibition via the steady state assumption.

Community: MathModDB

deterministic model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675358FDOQ6675358

Named after

Leonor Michaelis, Maud Menten

Contained entities

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

uni uni reaction (Michaelis Menten model without product - steady state assumption)
enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

Michaelis Menten equation (uni uni reaction without product and competitive complete inhibition - steady state assumption)	$v_{0} = \frac{V_{m a x, f} c_{S}}{c_{S} + K_{S} (1 + \frac{c_{I}}{K_{i c}})}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

mass balance	$δ_{t} + \nabla F = 0$
	$t$ represents time

Computational tasks

nonlinear parameter estimation (uni uni reaction without product and competitive complete inhibition - Michaelis Menten model - steady state assumption)

Assumptions

steady state assumption

References

Enzyme Kinetics	(review)

Linearizations

uni uni reaction competitive complete inhibition (Dixon model without product - steady state assumption), uni uni reaction competitive complete inhibition (Eadie Hofstee model without product - steady state assumption), uni uni reaction competitive complete inhibition (Hanes Woolf model without product - steady state assumption), uni uni reaction competitive complete inhibition (Lineweaver Burk model without product - steady state assumption)

Further links

Item	Property
initial reaction rate of uni uni reaction without product and competitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by
uni uni reaction mixed complete inhibition (Michaelis Menten model without product - steady state assumption)	contains
uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)	contains

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