uni uni reaction non-competitive complete inhibition (Dixon model without product - steady state assumption)

Community: MathModDB

deterministic model

linear model

mathematical model

static model

Available identifiers

MaRDI QIDQ6675366

uni uni reaction Dixon model without product and non-competitive complete Inhibition via the steady state assumption, named after Malcolm Dixon

List of contained entities

Dixon equation (uni uni reaction without product and non-competitive complete inhibition - steady state assumption)	$\frac{1}{v_0}=\frac{1}{V_{max,f}}(1+\frac{K_m}{c_S})+\frac{c_I}{V_{max,f}}(\frac{1}{K_{iu}}+\frac{K_m}{K_{ic}*c_S})$
	$K_S$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{ic}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{iu}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{max,f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_I$ represents inhibitor concentration
	$c_S$ represents substrate concentration
	$v_0$ represents initial reaction rate
enzyme conservation	$c_{E_0}=c_E+c_{EX}$
	$c_{EX}$ represents complexed enzyme concentration
	$c_{E_0}$ represents enzyme concentration
	$c_E$ represents enzyme concentration
initial inhibitor concentration (uni uni reaction)	$c_I(t=0)=c_{I_0}$	initial condition
	$c_I$ represents inhibitor concentration
	$t$ represents time
initial product concentration (uni uni reaction without product)	$c_P(t=0)=0$	initial condition
	$c_P$ represents product concentration
	$t$ represents time
initial substrate concentration (uni uni reaction)	$c_S(t=0)=c_{S_0}$	initial condition
	$c_S$ represents substrate concentration
	$t$ represents time
law of mass action	$v=k\prod _{i=1}^n{c}_i$
	$c_i$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate
mass balance	${\delta }_t+\mathrm{\nabla }F=0$
non-competitive enzyme inhibition coupling condition (uni uni reaction)	$\begin{array}{cc}{k}_1& =k_5\\ k_{-1}& =k_{-5}\\ k_{-3}& =k_{-4}\\ k_3& =k_4\\ K_{ic}& =K_{iu}\\ \end{array}$	coupling condition
	$k_1$ represents reaction rate constant
	$k_{-1}$ represents reaction rate constant
	$k_3$ represents reaction rate constant
	$k_{-3}$ represents reaction rate constant
	$k_4$ represents reaction rate constant
	$k_{-4}$ represents reaction rate constant
	$k_5$ represents reaction rate constant
	$k_{-5}$ represents reaction rate constant
	$K_{ic}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{iu}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
uni uni reaction (Michaelis Menten model without product - steady state assumption)
uni uni reaction competitive complete inhibition (Dixon model without product - steady state assumption)
uni uni reaction uncompetitive complete inhibition (Dixon model without product - steady state assumption)

List of computational tasks

linear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Dixon model - steady state assumption)

List of assumptions

steady state assumption

Described at:

Enzyme Kinetics

(review)

Further items linking to uni uni reaction non-competitive complete inhibition (Dixon model without product - steady state assumption)

Item	Property
initial reaction rate of uni uni reaction without product and non-competitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by
uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)	linearized by

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