Uni uni reaction non-competitive complete inhibition (Eadie Hofstee model without product - steady state assumption)

uni uni reaction Eadie-Hofstee model without product and non-competitive complete Inhibition via the steady state assumption.

Community: MathModDB

deterministic model	linear model	mathematical model	static model

Available identifiers

MaRDI QIDQ6675367FDOQ6675367

Named after

George Sharpe Eadie, Barend Hendrik Jan Hofstee

Contained entities

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

non-competitive enzyme inhibition coupling condition (uni uni reaction)	$\begin{matrix} k_{1} & = k_{5} \\ k_{- 1} & = k_{- 5} \\ k_{- 3} & = k_{- 4} \\ k_{3} & = k_{4} \\ K_{i c} & = K_{i u} \end{matrix}$	coupling condition
	$k_{1}$ represents reaction rate constant
	$k_{- 1}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$k_{5}$ represents reaction rate constant
	$k_{- 5}$ represents reaction rate constant
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

Eadie Hofstee equation (uni uni reaction without product and non-competitive complete inhibition - steady state assumption)	$v_{0} = \frac{V_{m a x, f}}{1 + \frac{c_{I}}{K_{i u}}} - \frac{K_{m} (1 + \frac{c_{I}}{K_{i c}})}{1 + \frac{c_{I}}{K_{i u}}} \frac{v_{0}}{c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

uni uni reaction competitive complete inhibition (Eadie Hofstee model without product - steady state assumption)
uni uni reaction uncompetitive complete inhibition (Eadie Hofstee model without product - steady state assumption)
uni uni reaction (Michaelis Menten model without product - steady state assumption)
mass balance	$δ_{t} + \nabla F = 0$
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

Computational tasks

linear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Eadie Hofstee model - steady state assumption)

Assumptions

steady state assumption

References

Enzyme Kinetics	(review)

Further links

Item	Property
initial reaction rate of uni uni reaction without product and non-competitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by
uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)	linearized by

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