uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)

Community: MathModDB

deterministic model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675370

uni uni reaction Michaelis Menten model without product and non-competitive complete Inhibition via the steady state assumption, named after Leonor Michaelis, Maud Menten

List of contained entities

Michaelis Menten equation (uni uni reaction without product and non-competitive complete inhibition - steady state assumption)	$v_{0} = \frac{V_{m a x, f} c_{S}}{(1 + \frac{c_{I}}{K_{i c}}) K_{S} + (1 + \frac{c_{I}}{K_{i u}}) c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

mass balance	$δ_{t} + \nabla F = 0$
non-competitive enzyme inhibition coupling condition (uni uni reaction)	$\begin{matrix} k_{1} & = k_{5} \\ k_{- 1} & = k_{- 5} \\ k_{- 3} & = k_{- 4} \\ k_{3} & = k_{4} \\ K_{i c} & = K_{i u} \end{matrix}$	coupling condition
	$k_{1}$ represents reaction rate constant
	$k_{- 1}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$k_{5}$ represents reaction rate constant
	$k_{- 5}$ represents reaction rate constant
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

uni uni reaction (Michaelis Menten model without product - steady state assumption)
uni uni reaction competitive complete inhibition (Michaelis Menten model without product - steady state assumption)
uni uni reaction uncompetitive complete inhibition (Michaelis Menten model without product - steady state assumption)

List of computational tasks

nonlinear parameter estimation (uni uni reaction without product and non-competitive complete inhibition - Michaelis Menten model - steady state assumption)

List of assumptions

steady state assumption

Described at:

Enzyme Kinetics	(review)

Linearized by the following models

uni uni reaction non-competitive complete inhibition (Dixon model without product - steady state assumption)
uni uni reaction non-competitive complete inhibition (Eadie Hofstee model without product - steady state assumption)
uni uni reaction non-competitive complete inhibition (Hanes Woolf model without product - steady state assumption)
uni uni reaction non-competitive complete inhibition (Lineweaver Burk model without product - steady state assumption)

Further items linking to uni uni reaction non-competitive complete inhibition (Michaelis Menten model without product - steady state assumption)

Item	Property
initial reaction rate of uni uni reaction without product and non-competitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by

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