Uni uni reaction non-competitive partial inhibition (Michaelis Menten model without product - steady state assumption)

uni uni reaction Dixon model without product and non-competitive partial Inhibition via the steady state assumption.

deterministic model	mathematical model	nonlinear model	static model

Available identifiers

MaRDI QIDQ6675371FDOQ6675371

Named after

Leonor Michaelis, Maud Menten

Contained entities

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

non-competitive enzyme inhibition coupling condition (uni uni reaction)	$\begin{matrix} k_{1} & = k_{5} \\ k_{- 1} & = k_{- 5} \\ k_{- 3} & = k_{- 4} \\ k_{3} & = k_{4} \\ K_{i c} & = K_{i u} \end{matrix}$	coupling condition
	$k_{1}$ represents reaction rate constant
	$k_{- 1}$ represents reaction rate constant
	$k_{3}$ represents reaction rate constant
	$k_{- 3}$ represents reaction rate constant
	$k_{4}$ represents reaction rate constant
	$k_{- 4}$ represents reaction rate constant
	$k_{5}$ represents reaction rate constant
	$k_{- 5}$ represents reaction rate constant
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

uni uni reaction competitive partial inhibition (Michaelis Menten model without product - steady state assumption)
enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

uni uni reaction (Michaelis Menten model without product - steady state assumption)
Michaelis Menten equation (uni uni reaction without product and non-competitive partial inhibition - steady state assumption)	$v_{0} = \frac{(V_{m a x, f} + \frac{V_{m a x, I, f} c_{I}}{K_{i u}}) c_{S}}{K_{S} (1 + \frac{c_{I}}{K_{i c}}) + (1 + \frac{c_{I}}{K_{i u}}) c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i c}$ represents competitive inhibition constant (uni uni reaction reversible inhibition)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, I, f}$ represents limiting reaction rate with inhibitor (uni uni reaction - forward)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

uni uni reaction uncompetitive partial inhibition (Michaelis Menten model without product - steady state assumption)
mass balance	$δ_{t} + \nabla F = 0$
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

Computational tasks

nonlinear parameter estimation (uni uni reaction without product and non-competitive partial inhibition - Michaelis Menten model - steady state assumption)

Assumptions

steady state assumption

References

Enzyme Kinetics	(review)

Further links

Item	Property
initial reaction rate of uni uni reaction without product and non-competitive partial inhibition	modelled by
uni uni reaction (ODE model)	specialized by

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