uni uni reaction uncompetitive complete inhibition (Eadie Hofstee model without product - steady state assumption)

Community: MathModDB

deterministic model	linear model	mathematical model	static model

Available identifiers

MaRDI QIDQ6675373

uni uni reaction Eadie Hofstee model without product and uncompetitive complete Inhibition via the steady state assumption, named after Barend Hendrik Jan Hofstee, George Sharpe Eadie

List of contained entities

Eadie Hofstee equation (uni uni reaction without product and uncompetitive complete inhibition - steady state assumption)	$v_{0} = \frac{V_{m a x, f}}{1 + \frac{c_{I}}{K_{i u}}} - \frac{K_{S}}{1 + \frac{c_{I}}{K_{i u}}} \frac{v_{0}}{c_{S}}$
	$K_{S}$ represents Michaelis constant substrate (uni uni reaction - steady state assumption)
	$K_{i u}$ represents uncompetitive inhibition constant (uni uni reaction reversible inhibition)
	$V_{m a x, f}$ represents limiting reaction rate (uni uni reaction - forward)
	$c_{I}$ represents inhibitor concentration
	$c_{S}$ represents substrate concentration
	$v_{0}$ represents initial reaction rate

enzyme conservation	$c_{E_{0}} = c_{E} + c_{E X}$
	$c_{E X}$ represents complexed enzyme concentration
	$c_{E_{0}}$ represents enzyme concentration
	$c_{E}$ represents enzyme concentration

initial inhibitor concentration (uni uni reaction)	$c_{I} (t = 0) = c_{I_{0}}$	initial condition
	$c_{I}$ represents inhibitor concentration
	$t$ represents time

initial product concentration (uni uni reaction without product)	$c_{P} (t = 0) = 0$	initial condition
	$c_{P}$ represents product concentration
	$t$ represents time

initial substrate concentration (uni uni reaction)	$c_{S} (t = 0) = c_{S_{0}}$	initial condition
	$c_{S}$ represents substrate concentration
	$t$ represents time

law of mass action	$v = k \prod_{i = 1}^{n} c_{i}$
	$c_{i}$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate

mass balance	$δ_{t} + \nabla F = 0$
uni uni reaction (Michaelis Menten model without product - steady state assumption)

List of computational tasks

linear parameter estimation (uni uni reaction without product and uncompetitive complete inhibition - Eadie Hofstee model - steady state assumption)

List of assumptions

steady state assumption

Described at:

Enzyme Kinetics	(review)

Further items linking to uni uni reaction uncompetitive complete inhibition (Eadie Hofstee model without product - steady state assumption)

Item	Property
initial reaction rate of uni uni reaction without product and uncompetitive complete inhibition	modelled by
uni uni reaction (ODE model)	specialized by
uni uni reaction mixed complete inhibition (Eadie Hofstee model without product - steady state assumption)	contains
uni uni reaction non-competitive complete inhibition (Eadie Hofstee model without product - steady state assumption)	contains
uni uni reaction uncompetitive complete inhibition (Michaelis Menten model without product - steady state assumption)	linearized by

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