Hill model (dose-response)
| deterministic model | dimensional model | mathematical model | nonlinear model | static model |
Available identifiers
sigmoidal model describing cooperative dose–response behavior, named after Terrell L. Hill
The Hill model in dose–response analysis is an empirical pharmacodynamic model used to represent cooperative activation or inhibition by drugs or ligands. It describes how biological effect increases with concentration in a sigmoidal manner controlled by a cooperativity exponent. The model includes a maximal effect and a half-maximal concentration parameter, providing intuitive measures of efficacy and potency. When the cooperativity exponent equals one, the model reduces to the non-cooperative hyperbolic Emax model. The Hill dose–response model is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic modeling to analyze concentration–effect relationships.
List of contained entities
| Hill dose-response equation | |
| represents observed response | |
| represents half maximal effective concentration | |
| represents drug concentration | |
| represents Hill coefficient | |
| represents maximal response | |
List of computational tasks
| nonlinear parameter estimation (Hill dose-response model) |
Described at:
| Pharmacodynamic principles and the time course of immediate drug effects | (review) |
Mathematical models specializing Hill model (dose-response)
| Emax model | assumes | no cooperativity assumption |
Further items linking to Hill model (dose-response)
| Item | Property |
|---|---|
| dose-response analysis | modelled by |
This page was built for model: Hill model (dose-response)
