Modeling of reaction-diffusion transport into a core-shell geometry

DOI10.1016/J.JTBI.2018.09.026MaRDI QIDQ1716824zbMATH OpenOpenAlexWikidataFDO

Authors Clarence C. King, Amelia Ann Brown, Irmak Sargin, K. M. Bratlie, Scott P. Beckman

Publication date 5 February 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1808.06766

zbMATH Keywords

core-shell geometryMichaelis-Menten kineticspancreatic Langerhan isletsreaction-diffusion transport modeling

Mathematics Subject Classification ID

Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Abstract: Fickian diffusion into a core-shell geometry is modeled. The interior core mimics pancreatic Langerhan islets and the exterior shell acts as inert protection. The consumption of oxygen diffusing into the cells is approximated using Michaelis-Menten kinetics. The problem is transformed to dimensionless units and solved numerically. Two regimes are identified, one that is diffusion limited and the other consumption limited. A regression is fit that describes the concentration at the center of the cells as a function of the relevant physical parameters. It is determined that, in a cell culture environment, the cells will remain viable as long as the islet has a radius of around $142mum$ or less and the encapsulating shell has a radius of less than approximately $283mum$. When the islet is on the order of $100mum$ it is possible for the cells to remain viable in environments with as little as $4.6imes10^{-2}mol/m^{-3}$ $O_2$. These results indicate such an encapsulation scheme may be used to prepare artificial pancreas to treat diabetes.

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Cites work

• A numerical study of oxygen diffusion in a spherical cell with the Michaelis-Menten oxygen uptake kinetics
• An analytical solution for diffusion and nonlinear uptake of oxygen in a spherical cell
• Numerical modeling of oxygen diffusion in cells with Michaelis-Menten uptake kinetics

Cited in

(6)

• Topological shooting of solutions for Fickian diffusion into core-shell geometry
• Coupled reaction-diffusion transport into a core-shell geometry
• Well-posedness results for general reaction-diffusion transport of oxygen in encapsulated cells
• Profile likelihood analysis for a stochastic model of diffusion in heterogeneous media
• Reaction-diffusion transport into core-shell geometry: well-posedness and stability of stationary solutions
• Corrigendum to: ``Modeling of reaction-diffusion transport into a core-shell geometry

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