Modifiers of mutation rate in selectively fluctuating environments

DOI10.1016/J.SPA.2020.06.011MaRDI QIDQ2229564zbMATH OpenOpenAlexFDO

Authors Elisabeth Sester-Huss, Peter Pfaffelhuber, Franz Baumdicker

Publication date 18 February 2021

Published in Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1909.06241

zbMATH Keywords

fixation probabilityFleming-Viot processmodifier theoryfluctuation selectionmicrobial evolutionsecond order evolution

Mathematics Subject Classification ID

Problems related to evolution (92D15) Functional limit theorems; invariance principles (60F17)

Abstract: We study a mutation-selection model with a fluctuating environment. More precisely, individuals in a large population are assumed to have a modifier locus determining the mutation rate $uin[0,vartheta]$ at a second locus with types $vin[0,1]$. In addition, the environment fluctuates, meaning that individual types change their fitness at some high rate. Fitness only depends on the type of the second locus. We obtain general limit results for the evolution of the allele frequency distribution for rapidly fluctuating environments. As an application, we make use of the resulting Fleming-Viot process and compute the fixation probabilities for higher mutation rates in the special case of two bi-allelic loci in the limit of small fitness differences at the second locus.

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Cites work

• scientific article; zbMATH DE number 1713116 (Why is no real title available?)
• scientific article; zbMATH DE number 3951715 (Why is no real title available?)
• Environmental variation, fluctuating selection and genetic drift in subdivided populations
• Fleming–Viot Processes in Population Genetics
• Modifiers of mutation rate: A general reduction principle
• Probability Models for DNA Sequence Evolution
• Scaling limits of population and evolution processes in random environment
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Cited in

(6)

• The interaction between mobile DNAs and their hosts in a fluctuating environment
• Mutating away from your enemies: the evolution of mutation rate in a host-parasite system
• Evolution of transmission modifiers under frequency-dependent selection and transmission in constant or fluctuating environments
• The interaction of genetic drift and mutation with selection in a fluctuating environment
• Mutation rate evolution in replicator dynamics
• Life history and deleterious mutation rate coevolution

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