Multi-scale skeletal muscle model

high-fidelity coupled skeletal muscle model

mathematical model

MaRDI QIDQ7360760FDOCommunityMathModDB

Contained entities

motor neuron pool model
electrophysiological muscle model
motor neuron pool ODE system	$\begin{array}{cc}\frac{\text{d}{V}_{\text{m}}^{\text{d}}}{\text{d}t}& =\frac{1}{C_{\text{m}}^{\text{d}}}(-I_{\text{ion}}^{\text{d}}(V_{\text{m}}^{\text{d}})-I_{\text{C}}^{\text{d}}(V_{\text{m}}^{\text{d}},V_{\text{m}}^{\text{s}}))\\ \frac{\text{d}{V}_{\text{m}}^{\text{s}}}{\text{d}t}& =\frac{1}{C_{\text{m}}^{\text{s}}}(-I_{\text{ion}}^{\text{s}}(V_{\text{m}}^{\text{s}})-I_{\text{C}}^{\text{s}}(V_{\text{m}}^{\text{d}},V_{\text{m}}^{\text{s}})+I_{\text{spindle}}({\lambda }_{\text{f}},{\dot{\lambda }}_{\text{f}})+I_{\text{ext}})\end{array}$
	$t$ represents time
	$C_{\text{m}}$ represents membrane capacitance
	$I_{\text{C}}$ represents coupling current
	$I_{\text{ext}}$ represents neural input
	$I_{\text{ion}}$ represents ion current
	$I_{\text{spindle}}$ represents sensory organ current
	$V_{\text{m}}$ represents membrane potential
	${\lambda }_{\text{f}}$ represents fiber stretch
monodomain equation for action potential propagation	$\frac{\partial V_{\text{m}}^{\text{f}}}{\partial t}=\frac{1}{C_{\text{m}}^{\text{f}}}(\frac{1}{A_{\text{m}}}{\sigma }_{\text{eff}}\frac{{\partial }^2{V}_{\text{m}}^{\text{f}}}{\partial s^2}-I_{\text{ion}}(V_{\text{m}}^{\text{f}},𝐲)+S(V_{\text{m}}^{\text{s}}))\text{in}{\mathrm{\Omega }}_f$
	$C_{\mathrm{m}}^{\mathrm{f}}$ represents membrane capacitance
	$I_{\mathrm{i}\mathrm{o}\mathrm{n}}$ represents ion current
	$V_{\text{m}}^{\text{f}}$ represents membrane potential
	${\sigma }_{\mathrm{e}\mathrm{f}\mathrm{f}}$ represents effective conductivity
	$t$ represents time
	$\mathbf{\text{𝐲}}$ represents state variable
	$s$ represents position vector
	$A_m$ represents surface-area-to-volume ratio
Hodgkin-Huxley Razumova equation	$\begin{array}{c}\frac{\partial \mathbf{\text{𝐲}}}{\partial t}=G(\mathbf{\text{𝐲}},V_{\text{m}}^{\text{f}})\\ I_{\text{ion}}=I_{\text{ion}}(V_{\text{m}}^{\text{f}},\mathbf{\text{𝐲}})\end{array}$
	$𝐲$ represents state variable
	$V_{\text{m}}^{\text{f}}$ represents membrane potential
	$I_{\mathrm{i}\mathrm{o}\mathrm{n}}$ represents ion current
	$G$ represents Hogdkin-Huxley Razumova function
electrophysiological muscle ODE system	$\begin{array}{cccc}{\rho }_{\text{M}1}{\ddot{𝐱}}_{\text{M}1}& =𝜵\cdot ({𝐏}_{\text{passive}}({𝐅}_{\text{M}1})+{𝐏}_{\text{active}}({𝐅}_{\text{M}1},{\gamma }_{\text{M}1})-p_{\text{M}1}{𝐅}_{\text{M}1}^{-T}),& 𝜵\cdot {\dot{𝐱}}_{\text{M}1}=0& \text{in}{\mathrm{\Omega }}_{\text{M}1}\times [0,T_{\text{end}})\\ {\rho }_{\text{M}2}{\ddot{𝐱}}_{\text{M}2}& =𝜵\cdot ({𝐏}_{\text{passive}}({𝐅}_{\text{M}2})+{𝐏}_{\text{active}}({𝐅}_{\text{M}2},{\gamma }_{\text{M}2})-p_{\text{M}2}{𝐅}_{\text{M}2}^{-T}),& \mathrm{\nabla }\cdot {\dot{𝐱}}_{\text{M}2}=0& \text{in}{\mathrm{\Omega }}_{\text{M}2}\times [0,T_{\text{end}})\\ {\rho }_{\text{T}}{\ddot{𝐱}}_{\text{T}}& =𝜵\cdot ({𝐏}_{\text{passive}}({𝐅}_{\text{T}})-p_{\text{T}}{𝐅}_{\text{T}}^{-T}),& 𝜵\cdot {\dot{𝐱}}_{\text{T}}=0& \text{in}{\mathrm{\Omega }}_{\text{T}}\times [0,T_{\text{end}})\end{array}$
	$\ddot{𝐱}$ represents material point acceleration
	$\dot{𝐱}$ represents material point velocity
	$\gamma$ represents lumped activation parameter
	$𝐏$ represents Piola-Kirchhoff stress tensors
	$𝐱$ represents displacement muscle tendon
	$\rho$ represents material density
	$p$ represents pressure
	$t$ represents time
	$𝐅$ represents deformation
	$𝐲$ represents state variable
	${\lambda }_f$ represents fiber stretch
	${\dot{\lambda }}_f$ represents fiber contraction velocity

Further links

Item	Property
Deep VKOGA	based on
optimizing physiological parameters in amputation surgery	modelled by

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