multigrain
Find the optimal graphical multiple testing procedure for confirmatory clinical trials that test several hypotheses across endpoints, doses, or subpopulations. Choose the graph maximising an explicit gain-function: a user-defined measure of trial success that scores each possible set of rejected hypotheses. Given simulated p-values, search over hypothesis weights and transition weights to maximise expected trial success. Conventional power criteria are recovered and the family-wise error rate is strongly controlled due to the search being confined to graphical procedures. Described in Spiers, Grayling, Wheeler, and Mander (2026) "Gain-function optimisation of graphical multiple testing procedures for confirmatory clinical trials" <doi:10.48550/arXiv.2609.19994>.
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