Multiplicity adjustments in testing for bioequivalence

DOI10.1002/SIM.6247MaRDI QIDQ6918996zbMATH OpenFDO

Authors Steven Y. Hua, Siyan Xu, Ralph B. D'Agostino

Publication date 9 October 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.6247

zbMATH Keywords

alpha-adaptive procedurebioequivalenceclosed testFWERmultiplicity adjustmentTOST

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A stagewise rejective multiple test procedure based on a modified Bonferroni test
• Bioequivalence trials, intersection-union tests and equivalence confidence sets. With comments and a rejoinder by the authors
• Closed procedures are better and often admit a shortcut.
• Extension of adaptive alpha allocation methods for strong control of the family-wise error rate
• General solutions to multiple testing problems
• Inference of bioequivalence for log-normal distributed data with unspecified variances
• Numerical computation of multivariatet-probabilities with application to power calculation of multiple contrasts
• On closed testing procedures with special reference to ordered analysis of variance
• On familywise type I error control for multiplicity in equivalence trials with three or more treatments
• Statistical considerations in bioequivalence of two area under the concentration-time curves obtained from serial sampling data
• Traditional multiplicity adjustment methods in clinical trials

Cited in

(2)

• Comments on: ``Multiplicity adjustments in testing for bioequivalence
• Simultaneous confidence regions for multivariate bioequivalence

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