Nonlinear parameter estimation (Hill binding model)
This task performs nonlinear parameter estimation for the Hill binding model using equilibrium ligand-binding data. It determines the Hill binding constant, maximal occupancy, and the cooperativity exponent by fitting the nonlinear Hill binding equation directly to free-ligand concentrations and fractional binding measurements. Nonlinear regression avoids artifacts from linearization and produces accurate estimates across cooperative, non-cooperative, and anti-cooperative regimes. The resulting parameters quantify binding affinity, saturation behavior, and the degree of cooperative interaction among binding sites. This method is commonly applied in biochemistry, molecular biology, and systems biology to study cooperative ligand–macromolecule interactions.
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