On set-based association tests: insights from a regression using summary statistics

DOI10.1002/CJS.11584MaRDI QIDQ5094249zbMATH OpenOpenAlexFDO

Authors Yanyan Zhao, Lei Sun

Publication date 2 August 2022

Published in The Canadian Journal of Statistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1002/cjs.11584

zbMATH Keywords

correlationregressionset-based testssparse alternativessummary statistics

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Asymptotic properties of parametric tests (62F05) Hypothesis testing in multivariate analysis (62H15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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(8)

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• Bayesian large-scale multiple regression with summary statistics from genome-wide association studies
• Integrated quantile rank test (iQRAT) for gene-level associations
• Genetic association test based on principal component analysis
• Multiple phenotype association tests using summary statistics in genome-wide association studies
• REMI: REGRESSION WITH MARGINAL INFORMATION AND ITS APPLICATION IN GENOME-WIDE ASSOCIATION STUDIES
• Genetic variant set-based tests using the generalized Berk-Jones statistic with application to a genome-wide association study of breast cancer
• A stable and adaptive polygenic signal detection method based on repeated sample splitting

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