On the Calibration of a Size-Structured Population Model from Experimental Data

DOI10.1007/S10441-010-9114-9MaRDI QIDQ6215275zbMATH OpenWikidataFDO

Authors M. Doumic, Pedro D. Maia, J. P. Zubelli

Publication date 2 September 2009

Full work available at URL https://doi.org/10.1007/S10441-010-9114-9

Mathematics Subject Classification ID

Boundary value problems for linear first-order PDEs (35F15) Inverse problems for PDEs (35R30) Population dynamics (general) (92D25)

Abstract: The aim of this work is twofold. First, we survey the techniques developed in (Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct the division (birth) rate from the cell volume distribution data in certain structured population models. Secondly, we implement such techniques on experimental cell volume distributions available in the literature so as to validate the theoretical and numerical results. As a proof of concept, we use the data reported in the classical work of Kubitschek [3] concerning Escherichia coli in vitro experiments measured by means of a Coulter transducer-multichannel analyzer system (Coulter Electronics, Inc., Hialeah, Fla, USA.) Despite the rather old measurement technology, the reconstructed division rates still display potentially useful biological features.

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