On the analysis of tuberculosis studies with intermittent missing sputum data

DOI10.1214/15-AOAS860MaRDI QIDQ262414zbMATH OpenFDO

Authors Maria Abraham, Aidan McDermott, Richard Chaisson, Lawrence Geiter, Daniel Scharfstein, Andrea Rotnitzky

Publication date 29 March 2016

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1602.02891, https://projecteuclid.org/euclid.aoas/1453994198

zbMATH Keywords

culture conversioncurse of dimensionalityexponential tiltingreverse-time hazardsensitivity analysis

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In randomized studies evaluating treatments for tuberculosis (TB), individuals are scheduled to be routinely evaluated for the presence of TB using sputum cultures. One important endpoint in such studies is the time of culture conversion, the first visit at which a patient's sputum culture is negative and remains negative. This article addresses how to draw inference about treatment effects when sputum cultures are intermittently missing on some patients. We discuss inference under a novel benchmark assumption and under a class of assumptions indexed by a treatment-specific sensitivity parameter that quantify departures from the benchmark assumption. We motivate and illustrate our approach using data from a randomized trial comparing the effectiveness of two treatments for adult TB patients in Brazil.

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Cites work

• scientific article; zbMATH DE number 735225 (Why is no real title available?)
• scientific article; zbMATH DE number 1104326 (Why is no real title available?)
• scientific article; zbMATH DE number 3385132 (Why is no real title available?)
• Ignorability and coarse data
• Ignorability and Coarse Data: Some Biomedical Examples
• Ignorability in general incomplete-data models

Cited in

(1)

• Application of sensitivity analysis to incomplete longitudinal CD4 count data

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