On the stability of a nonlinear maturity structured model of cellular proliferation

DOI10.3934/DCDS.2005.12.501MaRDI QIDQ1770194zbMATH OpenOpenAlexFDO

Authors Mostafa Adimy, Fabien Crauste, Laurent Pujo-Menjouet

Publication date 11 April 2005

Published in Discrete and Continuous Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0904.2492

zbMATH Keywords

Blood production systemDelay depending on the maturityGlobal stabilityInstabilityMaturity structured modelNonlinear partial differential equation

Mathematics Subject Classification ID

Asymptotic behavior of solutions to PDEs (35B40) Nonlinear first-order PDEs (35F20) Cell biology (92C37) Population dynamics (general) (92D25)

Abstract: We analyse the asymptotic behaviour of a nonlinear mathematical model of cellular proliferation which describes the production of blood cells in the bone marrow. This model takes the form of a system of two maturity structured partial differential equations, with a retardation of the maturation variable and a time delay depending on this maturity. We show that the stability of this system depends strongly on the behaviour of the immature cells population. We obtain conditions for the global stability and the instability of the trivial solution.

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