Online error rate control for platform trials

DOI10.1002/SIM.9733MaRDI QIDQ6625787zbMATH OpenFDO

Authors David S. Robertson, James Wason, Franz Koenig, Martin Posch, Thomas Jaki

Publication date 28 October 2024

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.9733

zbMATH Keywords

multiple testingonline hypothesis testingplatform trialtype I error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A generalized Dunnett test for multi-arm multi-stage clinical studies with treatment selection
• Asynchronous online testing of multiple hypotheses
• Confident inference for SNP effects on treatment efficacy
• False discovery rate control with e-values
• Online rules for control of false discovery rate and false discovery exceedance

Cited in

(5)

• The online closure principle
• A multi-arm multi-stage platform design that allows preplanned addition of arms while still controlling the family-wise error
• An exhaustive ADDIS principle for online FWER control
• ADDIS-graphs for online error control with application to platform trials
• A preplanned multi-stage platform trial for discovering multiple superior treatments with control of FWER and power

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