Optimal adaptive allocation using deep reinforcement learning in a dose-response study

DOI10.1002/SIM.9247MaRDI QIDQ6626773zbMATH OpenFDO

Authors Kentaro Matsuura, Junya Honda, Imad El Hanafi, Takashi Sozu, Kentaro Sakamaki

Publication date 29 October 2024

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.9247

zbMATH Keywords

adaptive designclinical trialdose-findingdose-rangingoptimal designresponse-adaptive

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• BMA‐Mod: A Bayesian model averaging strategy for determining dose‐response relationships in the presence of model uncertainty
• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• Dose Finding – A Challenge in Statistics
• Group Sequential Clinical Trials: A Classical Evaluation of Bayesian Decision-Theoretic Designs
• Optimal designs for dose-finding studies
• Reinforcement learning. An introduction
• Response-adaptive dose-finding under model uncertainty

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