Optimal estimation for the functional Cox model
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Abstract: Functional covariates are common in many medical, biodemographic, and neuroimaging studies. The aim of this paper is to study functional Cox models with right-censored data in the presence of both functional and scalar covariates. We study the asymptotic properties of the maximum partial likelihood estimator and establish the asymptotic normality and efficiency of the estimator of the finite-dimensional estimator. Under the framework of reproducing kernel Hilbert space, the estimator of the coefficient function for a functional covariate achieves the minimax optimal rate of convergence under a weighted -risk. This optimal rate is determined jointly by the censoring scheme, the reproducing kernel and the covariance kernel of the functional covariates. Implementation of the estimation approach and the selection of the smoothing parameter are discussed in detail. The finite sample performance is illustrated by simulated examples and a real application.
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- LCox: a tool for selecting genes related to survival outcomes using longitudinal gene expression data
- Adaptive kernel estimation of the baseline function in the Cox model with high-dimensional covariates
- Functional censored quantile regression
- Modelling time-varying covariates effect on survival via functional data analysis: application to the MRC BO06 trial in osteosarcoma
- Estimating the functional form of a continuous covariate's effect on survival time
- Optimal estimation for the functional Cox model
- FLCRM: functional linear Cox regression model
- Semiparametric Inference for the Functional Cox Model
- Using persistent homology topological features to characterize medical images: case studies on lung and brain cancers
- Semiparametric estimation for the functional additive hazards model
- Estimating optimal step-function approximations to instantaneous hazard rates
- Cox regression models with functional covariates for survival data
- Additive Functional Cox Model
- Subgroup analysis in the heterogeneous Cox model
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