Optimal radiotherapy treatment planning using minimum entropy models

DOI10.1016/J.AMC.2012.08.099MaRDI QIDQ2017937zbMATH OpenOpenAlexFDO

Authors Richard C. Barnard, Martin Frank, Michael Herty

Publication date 23 March 2015

Published in Applied Mathematics and Computation (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1105.5261

zbMATH Keywords

optimizationminimum entropyradiotherapyBoltzmann transport

Mathematics Subject Classification ID

Medical applications (general) (92C50) Measures of information, entropy (94A17) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: We study the problem of finding an optimal radiotherapy treatment plan. A time-dependent Boltzmann particle transport model is used to model the interaction between radiative particles with tissue. This model allows for the modeling of inhomogeneities in the body and allows for anisotropic sources modeling distributed radiation---as in brachytherapy---and external beam sources---as in teletherapy. We study two optimization problems: minimizing the deviation from a spatially-dependent prescribed dose through a quadratic tracking functional; and minimizing the survival of tumor cells through the use of the linear-quadratic model of radiobiological cell response. For each problem, we derive the optimality systems. In order to solve the state and adjoint equations, we use the minimum entropy approximation; the advantages of this method are discussed. Numerical results are then presented.

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Cited in

(6)

• Optimal treatment planning in radiotherapy based on Boltzmann transport equations
• OPTIMAL TREATMENT PLANNING IN RADIOTHERAPY BASED ON BOLTZMANN TRANSPORT CALCULATIONS
• \(L^1\) penalization of volumetric dose objectives in optimal control of PDEs
• INVERSE RADIOTHERAPY TREATMENT PLANNING MODEL APPLYING BOLTZMANN-TRANSPORT EQUATION
• KiT-RT: an extendable framework for radiative transfer and therapy
• Multinomial model-based formulations of TCP and NTCP for radiotherapy treatment planning

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