Optimality of Unconstrained Pulse Inputs to the Bergman Minimal Model
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Abstract: We characterise optimality of bolus insulin inputs, to the Bergman minimal model, by the predicted behaviour of the plasma glucose concentration for a given disturbance. The result is derived subject to the constraints that the plasma glucose concentration must attain but not go below a specified minimum value and the bolus input is rectangular. We give numerical examples of the results for the Hovorka model.
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